Research

My interests are in the following areas: pharmacoepidemiology, cancer epidemiology, cardiovascular epidemiology, theoretical epidemiology, theory of clinical research.

My current research comprises the following projects:

1)     Development and validation of a lung cancer risk prediction model.
2)     The GENESIS PRAXY (PRemature Acute Coronary SYndrome) Study.
3)     Effect modification of gene-mediated susceptibility to myocardial infarction by sex and other conventional risk factors.

I am also collaborating with the following studies:
4) The NDIT (Nicotine Dependence in Teens) Study (PI: Dr. J.O’Loughlin)
5) The DOVE (Detecting OVarian cancer Earlier) Study (PI: Dr. L.Gilbert)
6) Exploring sex differences in the efficacy of cardioprotective medications: a series of meta-analyses
(PI: Dr. D.Rabi)

Education and training

Other affiliations

Publications

1. O’Loughlin J, Karp I, Koulis T, Paradis G, DiFranza J. Determinants of first puff and daily cigarette smoking in adolescents. American Journal of Epidemiology 2009 (Accepted).
2. Filion KB, Schneider-Lindner V, Karp I, Levesque L, Brophy JB, Suissa S. Continuation of statins and mortality: A note of caution on excessive benefits. [Letter] Archives of Internal Medicin 2009 (Accepted).
3. Karp I, Pilote L. Statins and cancer risk: decrease or increase? [Letter] American Journal of Medicine 2008; 121:e19.
4. Karp I, Behlouli H, Lelorier J, Pilote L. Statins and cancer risk. American Journal of Medicine 2008; 121:302-309.
5. O’Loughlin J, Karp I, Henderson M, Gray-Donald K. Does cigarette use influence adiposity or height in adolescents? Annals of Epidemiology 2008; 18:395-402.
6. O’Loughlin J, Lambert M, Karp I, McGrath J, Gray-Donald K, Barnett TA, Delvin E, Levy EE, Paradis G. Association between cigarette smoking and C-reactive protein in a representative, population-based sample of adolescents. Nicotine & Tobacco Research 2008; 10:525-532.
7. Karp I, Abrahamowicz M, Fortin P, Pilote L, Neville C, Pineau C, Esdaile J. Recent corticosteroid use and recent disease activity: are they independent determinants of coronary heart disease risk factors in systemic lupus erythematosus? Arthritis Care and Research 2008; 59:169-175.
8. Karp I, Topol E, Pilote L. Population attributable fraction: its implications for genetic epidemiology and illness prevention. [Editorial] American Heart Journal 2007; 154:607-609.
9. Karp I, Chen SF, Pilote L. Sex differences in the effectiveness of statins in patients after myocardial infarction. Canadian Medical Association Journal, 2007; 176:333-338.
10. Kulaga S, Karp I. Mammographic screening from age 40 years. [Letter] Lancet 2007; 369:738-739.
11. Kulaga S, Karp I. CT screening for lung cancer. [Letter] New England Journal of Medicine 2007; 356:745.
12. O’Loughlin J, Makni H, Tremblay M, Karp I. Gender differences among general practitioners in smoking cessation counseling practices. Preventive Medicine 2007; 45:208-214.
13. Karp I, O’Loughlin J, Hanley J, Tyndale R, Paradis G. Risk factors for nicotine dependence in adolescent smokers. Tobacco Control 2006; 15:199-204.
14. Dasgupta K, O’Loughlin J, Chen SF, Karp I, Paradis G, Tremblay J, Hamet P, Pilote L. Emergence of sex differences in prevalence of high systolic blood pressure: Analysis of a longitudinal adolescent cohort. Circulation, 2006; 114:2663-2670.
15. Pineau C, Bernatsky S, Abrahamowicz M, Neville C, Karp I, Clarke A. A comparison of damage accrual across different calendar periods in SLE patients. Lupus, 2006; 15:590-594.
16. Karp I, O’Loughlin J, Paradis G, Hanley J, DiFranza J. Smoking trajectories of novice smokers in a longitudinal study of tobacco use. Annals of Epidemiology 2005; 15:445-452.
17. De Civita M, Dobkin PL, Feldman DE, Karp I, Duffy C. Development and preliminary reproducibility and validity of the Parent Adherence Report Questionnaire: A measure of adherence in juvenile idiopathic arthritis. Journal of Clinical Psychology in Medical Settings 2005; 12:1-12.
18. Bernatsky S, Pineau C, Abrahamowicz M, Neville C, Karp I, Clarke A. A comparison of retrospective and prospective evaluations of the SLICC/ACR Damage Index scores for systemic lupus erythematosus (SLE). Journal of Rheumatology 2005; 32:820-823.
19. Dendukuri N, McCusker J, Bellavance F, Cardin S, Verdon J, Karp I, Belzile E.  Comparing the validity of different sources of information on emergency department visits: a latent class analysis. Medical Care 2005; 43:266-275.
20. Karp I, Abrahamowicz M, Bartlett G, Pilote L. Updated risk factor values improve the ability of the multivariable risk score to predict coronary heart disease. American Journal of Epidemiology 2004; 160:707-716.
21. Pilote L, Beck CA, Karp I, Alter D, Austin P, Cox J, Humphries K, Jackevicius C, Richard H, Tu JV. Secondary prevention after acute myocardial infarction in four Canadian provinces, 1997-2000. Canadian Journal of Cardiology 2004; 20:61-67.
22. Pilote L, Merrett P, Karp I, Alter D, Austin P, Cox J, Johansen H, Ghali W, Tu JV. Cardiac procedures after an acute myocardial infarction across nine Canadian provinces. Canadian Journal of Cardiology 2004; 20:491-500.
23. McCusker J, Karp I, Cardin S, Durand P, Morin J. Determinants of emergency department visits by older adults: A Systematic Review. Academic Emergency Medicine 2003; 10:1362-1370.